Berikut adalah senarai pemenang malam kemuncak Shout! Award 2010:
Rockstar Award (Rock Award) - Bunkface
Favourite TV Personality Award - Zizan Raja Lawak
Breakthrough Feature Award - Lagenda Budak Setan (Sharad Sharan)
Popstar Award (Pop Award) - Yuna
Power Vocal Award (Powerful Vocal Award) - Faizal Tahir
Fresh TV Series Award - Nur Kasih (Filmscape)
Favourite TV Program (Non Drama) - Showdown 2010
Music Video Award - Prom Queen (Bunkface)
Flava Award (Hip Hop/R&B Awards) - Mizz Nina
Hot Guy Award - Henry Golding
Hot Chick Award - Scha Al-Yahya
Coolest Radio Announcer Award - Phat Fabes (Fly FM Pagi Show)
Favourite Radio Show - HotFM AM Krew (Fara, Faizal & A.G)
Best On-Screen Chemistry Award - Afdlin Shauki & Liyana Jasmay (Papadom)
Mobile Artist Of The Year - 6ixth Sense (Tanpa)
Break Out Award (Best New Act) - Yuna